BACKGROUND/ABSTRACT: Immune responses initiated by T cell receptor (TCR) and costimulatory molecule mediated signaling culminate in maximal cytokine mRNA production and stability. The transcriptional responses to co-stimulatory T cell signalling involve calcineurin and NF-AT. which can be antagonized by interference with the cis-trans peptidyl-prolyl isomerases (PPIase). cyclophilin A... https://pinkscherryers.shop/product-category/lubes-and-lotions/